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CD99 expression is strongly associated with clinical outcome in children with B-cell precursor acute lymphoblastic leukaemia

Journal article
Authors Dongfeng Chen
Alessandro Camponeschi
Qingqing Wu
Natalija Gerasimcik
Huiqi Li
Xue Shen
Yujie Tan
Helene Sjögren
Jessica Nordlund
Gudmar Lönnerholm
Jonas Abrahamsson
Linda Fogelstrand
Inga-Lill Mårtensson
Published in British Journal of Haematology
Volume 184
Issue 3
Pages 418-423
ISSN 0007-1048
Publication year 2019
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Institute of Biomedicine
Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine
Institute of Clinical Sciences, Department of Pediatrics
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 418-423
Language en
Links doi.org/10.1111/bjh.15683
Keywords acute leukaemia, BCP-ALL, biomarker, CD99, prognosis
Subject categories Hematology, Cancer and Oncology, Cell and Molecular Biology

Abstract

Our study aimed to determine the expression pattern and clinical relevance of CD99 in paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). Our findings demonstrate that high expression levels of CD99 are mainly found in high-risk BCP-ALL, e.g. BCR-ABL1 and CRLF2 Re/Hi, and that high CD99 mRNA levels are strongly associated with a high frequency of relapse, high proportion of positive for minimal residual disease at day 29 and poor overall survival in paediatric cohorts, which indicate that CD99 is a potential biomarker for BCP-ALL.

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