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International validation of the revised European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ-HN43: Phase IV.

Journal article
Authors Susanne Singer
Cecilie Delphin Amdal
Eva Hammerlid
Iwona M Tomaszewska
Joaquim Castro Silva
Hisham Mehanna
Marcos Santos
Johanna Inhestern
Christine Brannan
Noam Yarom
Amy Fullerton
Monica Pinto
Juan I Arraras
Naomi Kiyota
Pierluigi Bonomo
Allen C Sherman
Ingo Baumann
Razvan Galalae
Loreto Fernandez Gonzalez
Ourania Nicolatou-Galitis
Zeinab Abdel-Hafeez
Judith Raber-Durlacher
Claudia Schmalz
Paola Zotti
Andreas Boehm
Dirk Hofmeister
Sanja Krejovic Trivic
Suat Loo
Wei-Chu Chie
Kristin Bjordal
Bente Brokstad Herlofson
Vincent Grégoire
Lisa Licitra
Published in Head & neck
Volume 41
Issue 6
Pages 1725-1737
ISSN 1097-0347
Publication year 2019
Published at Institute of Clinical Sciences, Department of Otorhinolaryngology
Institute of Clinical Sciences
Pages 1725-1737
Language en
Links dx.doi.org/10.1002/hed.25609
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Cancer and Oncology

Abstract

We validated the new European Organisation for Research and Treatment of Cancer Quality of Life Head and Neck Module (EORTC QLQ-HN43).We enrolled 812 patients with head and neck cancer from 18 countries. Group 1 completed the questionnaire before therapy, and 3 and 6 months later. In group 2 (survivors), we determined test-retest reliability using intraclass correlation coefficients (ICC). Internal consistency was assessed using Cronbach's Alpha, the scale structure with confirmatory factor analysis, and discriminant validity with known-group comparisons.Cronbach's alpha was >0.70 in 10 of the 12 multi-item scales. All standardized factor loadings exceeded 0.40. The ICC was >0.70 in all but two scales. Differences in scale scores between known-groups were >10 points in 17 of the 19 scales. Sensitivity to change was found to be sufficient in 18 scales.Evidence supports the reliability and validity of the EORTC QLQ-HN43 as a measure of quality of life.

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