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Altered Lipid Composition of Secretory Cells Following Exposure to Zinc Can Be Correlated to Changes in Exocytosis

Journal article
Authors Lin Ren
Masoumeh Dowlatshahi Pour
Per Malmberg
Andrew G Ewing
Published in Chemistry - A European Journal
Volume 25
Issue 21
Pages 5406-5411
ISSN 0947-6539
Publication year 2019
Published at Department of Chemistry and Molecular Biology
National Center for Imaging Mass Spectrometry
Pages 5406-5411
Language en
Keywords amperometry, lipid compostition, regulated exocytosis, vesicle content, zinc
Subject categories Analytical Chemistry


© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim A micromolar concentration of zinc has been shown to significantly change the dynamics of exocytosis as well as the vesicle contents in a model cell line, providing direct evidence that zinc regulates neurotransmitter release. To provide insight into how zinc modulates these exocytotic processes, neurotransmitter release and vesicle content were compared with single cell amperometry and intracellular impact vesicle cytometry with a range of zinc concentrations. Additionally, time-of-flight secondary ion mass spectrometry (ToF-SIMS) images of lipid distributions in the cell membrane after zinc treatment correlate to changes in exocytosis. By combining electrochemical techniques and mass spectrometry imaging, we proposed a mechanism by which zinc changes the fusion pore and the rate of neurotransmitter release by changing lipid distributions and results in the modulation of synaptic strength and plasticity.

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