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Moyamoya angiopathy: long-term follow-up study in a Finnish population

Journal article
Authors M. Savolainen
S. Mustanoja
J. Pekkola
T. Tyni
A. M. Uusitalo
S. Ruotsalainen
E. Poutiainen
J. Hernesniemi
L. Kivipelto
Turgut Tatlisumak
Published in Journal of Neurology
Volume 266
Issue 3
Pages 574-581
ISSN 0340-5354
Publication year 2019
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
Pages 574-581
Language en
Keywords Stroke, Moyamoya angiopathy, Treatment, Prognosis, Follow-up, Quality of life, Mood symptoms, quality-of-life, cognition
Subject categories Neurosciences


Background and purposeMoyamoya angiopathy (MMA) is a chronic cerebrovascular disorder predominantly starting in childhood or early adulthood and thus affects the whole lifetime. Little is known on MMAs long-term outcomes in European patients. We report long-term follow-up data on Finnish MMA patients.MethodsWe included patients from our Helsinki University Hospital MMA database and arranged long-term follow-up visits for all the patients. This follow-up included a review of the medical records accumulated in due time, detailed neurological and neuropsychological evaluation, and outcome measures modified Rankin Scale (mRS) and Barthel Index (BI).ResultsThere were 61 MMA patients with a mean follow-up period of 9.5years (SD 6.7years; range 1.3-35.4years; 581 patient-years). Only two patients had died and two-thirds (n=40, 65.6%) had no new events during the follow-up period. Eight patients (13.1%) had an ischemic and five patients (8.2%) a hemorrhagic stroke during the follow-up. There were no differences between operated (n=26) and conservatively (n=35) treated groups regarding recurrent events or the outcome measured with mRS or BI. Finnish MMA patients reported significantly poorer physical and psychological health aspects of QOL when compared to the general Finnish population. Symptoms of low mood were found in 27 (56%) patients.ConclusionsFinnish MMA patients have a benign and stable course with a 3.5% annual stroke risk. We found no differences in the clinical outcomes between the operated and conservative groups, however, the psychosocial well-being requires more attention in MMA patients.

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