To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

DNA-stimulated cell death… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer

Journal article
Authors Sören R Paludan
L. S. Reinert
V. Hornung
Published in Nature Reviews Immunology
Volume 19
Issue 3
Pages 141-153
ISSN 1474-1733
Publication year 2019
Published at Institute of Biomedicine
Pages 141-153
Language en
Keywords cyclic gmp-amp, systemic-lupus-erythematosus, innate immune recognition, herpes-simplex-virus, toll-like receptors, domain-like protein, kappa-b, activation, cytosolic-DNA, aim2 inflammasome, i interferon
Subject categories Immunology in the medical area


The immune system detects disturbances in homeostasis that occur during infection, sterile tissue damage and cancer. This initiates immune responses that seek to eliminate the trigger of immune activation and to re-establish homeostasis. At the same time, these mechanisms can also play a crucial role in the progression of disease. The occurrence of DNA in the cytosol constitutes a potent trigger for the innate immune system, governing the production of key inflammatory cytokines such as type I interferons and IL-1 beta. More recently, it has become clear that cytosolic DNA also triggers other biological responses, including various forms of programmed cell death. In this article, we review the emerging literature on the pathways governing DNA-stimulated cell death and the current knowledge on how these processes shape immune responses to exogenous and endogenous challenges.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?