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Tuesday 25 June 11:30

DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer

Journal article
Authors Sören R Paludan
L. S. Reinert
V. Hornung
Published in Nature Reviews Immunology
Volume 19
Issue 3
Pages 141-153
ISSN 1474-1733
Publication year 2019
Published at Institute of Biomedicine
Pages 141-153
Language en
Links dx.doi.org/10.1038/s41577-018-0117-...
Keywords cyclic gmp-amp, systemic-lupus-erythematosus, innate immune recognition, herpes-simplex-virus, toll-like receptors, domain-like protein, kappa-b, activation, cytosolic-DNA, aim2 inflammasome, i interferon
Subject categories Immunology in the medical area

Abstract

The immune system detects disturbances in homeostasis that occur during infection, sterile tissue damage and cancer. This initiates immune responses that seek to eliminate the trigger of immune activation and to re-establish homeostasis. At the same time, these mechanisms can also play a crucial role in the progression of disease. The occurrence of DNA in the cytosol constitutes a potent trigger for the innate immune system, governing the production of key inflammatory cytokines such as type I interferons and IL-1 beta. More recently, it has become clear that cytosolic DNA also triggers other biological responses, including various forms of programmed cell death. In this article, we review the emerging literature on the pathways governing DNA-stimulated cell death and the current knowledge on how these processes shape immune responses to exogenous and endogenous challenges.

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