To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

A Novel Class of Injectab… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

A Novel Class of Injectable Bioceramics That Glue Tissues and Biomaterials

Journal article
Authors M. Pujari-Palmer
H. Guo
D. Wenner
H. Autefage
C. D. Spicer
M. M. Stevens
Omar Omar
Peter Thomsen
M. Eden
G. Insley
P. Procter
H. Engqvist
Published in Materials
Volume 11
Issue 12
ISSN 1996-1944
Publication year 2018
Published at Institute of Clinical Sciences, Department of Biomaterials
Language en
Keywords cement, tissue adhesive, phosphoserine, self-assembly, amorphous calcium phosphate (ACP), calcium-phosphate cement, amino-acids, l-serine, bone, adhesives, localization, osteopontin, phase
Subject categories Biomaterials Science


Calcium phosphate cements (CPCs) are clinically effective void fillers that are capable of bridging calcified tissue defects and facilitating regeneration. However, CPCs are completely synthetic/inorganic, unlike the calcium phosphate that is found in calcified tissues, and they lack an architectural organization, controlled assembly mechanisms, and have moderate biomechanical strength, which limits their clinical effectiveness. Herein, we describe a new class of bioinspired CPCs that can glue tissues together and bond tissues to metallic and polymeric biomaterials. Surprisingly, alpha tricalcium phosphate cements that are modified with simple phosphorylated amino acid monomers of phosphoserine (PM-CPCs) bond tissues up to 40-fold stronger (2.5-4 MPa) than commercial cyanoacrylates (0.1 MPa), and 100-fold stronger than surgical fibrin glue (0.04 MPa), when cured in wet-field conditions. In addition to adhesion, phosphoserine creates other novel properties in bioceramics, including a nanoscale organic/inorganic composite microstructure, and templating of nanoscale amorphous calcium phosphate nucleation. PM-CPCs are made of the biocompatible precursors calcium, phosphate, and amino acid, and these represent the first amorphous nano-ceramic composites that are stable in liquids.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?