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Systems analysis of human vaccine adjuvants

Journal article
Authors Ali M Harandi
Published in Seminars in Immunology
Volume 39
Issue C (Special Issue: SI )
Pages 30-34
ISSN 1044-5323
Publication year 2018
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 30-34
Language en
Links dx.doi.org/10.1016/j.smim.2018.08.0...
Keywords Vaccine, Adjuvant, Vaccinology, Systems vaccinology, Omics, Transcriptomics, molecular signatures, seasonal influenza, tuberculosis, immunogenicity, inflammasome, responses, biology, alum, mf59, Immunology
Subject categories Immunology in the medical area

Abstract

The discovery and wide spread use of vaccines have saved millions of lives in the past few decades. Vaccine adjuvants represent an integral part of the modem vaccines. Despite numerous efforts, however, only a handful of vaccine adjuvants is currently available for human use. A comprehensive understanding of the mechanisms of action of adjuvants is pivotal to harness the potential of existing and new adjuvants in mounting desirable immune responses to counter human pathogens. Decomposing the host response to vaccines and its components at systems level has recently been made possible owing to the recent advancements in Omics technology and cutting edge immunological assays powered by systems biology approaches. This approach has begun to shed light on the molecular signatures of several human vaccines and adjuvants. This review is an attempt to provide an overview of the recent efforts in systems analysis of vaccine adjuvants that are currently in clinic.

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