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Case fatality ratio and mortality rate trends of community-onset Staphylococcus aureus bacteraemia

Journal article
Authors S. Tom
J. C. Galbraith
L. Valiquette
Gunnar Jacobsson
P. Collignon
H. C. Schonheyder
M. Sogaard
K. J. Kennedy
J. D. Knudsen
C. Ostergaard
O. Lyytikainen
K. B. Laupland
Published in Clinical Microbiology and Infection
Volume 20
Issue 10
Pages O630-O632
ISSN 1198-743X
Publication year 2014
Published at
Pages O630-O632
Language en
Subject categories Internal medicine


Lethal outcomes can be expressed as a case fatality ratio (CFR) or as a mortality rate per 100000 population per year (MR). Population surveillance for community-onset methicillin-sensitive (MSSA) and methicillin-resistant (MRSA) Staphylococcus aureus bacteraemia was conducted in Canada, Australia, Sweden and Denmark to evaluate 30-day CFR and MR trends between 2000 and 2008. The CFR was 20.3% (MSSA 20.2%, MRSA 22.3%) and MR was 3.4 (MSSA 3.1, MRSA 0.3) per 100000 per year. Although MSSA CFR was stable the MSSA MR increased; MRSA CFR decreased while its MR remained low during the study. Community-onset S.aureus bacteraemia, particularly MSSA, is associated with major disease burden. This study highlights complementary information provided by evaluating both CFR and MR.

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