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Low Serum IGF-1 in Boys with Recent Onset of Juvenile Idiopathic Arthritis

Journal article
Authors Anna-Carin Lundell
Malin Erlandsson
Maria Bokarewa
H. Liivamagi
K. Uibo
S. Tarraste
T. Rebane
T. Talvik
C. Pruunsild
Rille Pullerits
Published in Journal of Immunology Research
ISSN 2314-8861
Publication year 2018
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Language en
Keywords growth-factor-i, rheumatoid-arthritis, insulin-resistance, hormone-secretion, disease-activity, children, cytokines, association, prevalence, experience
Subject categories Immunology in the medical area


Background. Liver-derived insulin-like growth factor-1 (IGF-1) contributes bone formation. Decreased IGF-1 levels are common in juvenile idiopathic arthritis (JIA), but whether IGF-1 is related to sex and differ during the pathogenic progress of JIA is unknown. Objective. The aim of this study was to examine IGF-1 levels in boys and girls with newly diagnosed JIA, with established JIA and in controls. Methods. The study group included 131 patients from the Estonian population-based prevalence JIA study. Blood samples were obtained from 27 boys and 38 girls with early JIA (<= 1 month from the diagnosis), 29 boys and 36 girls with established JIA (mean disease duration 18 months), and from 47 age- and sex-matched controls. Results. IGF-1 levels in boys were significantly decreased in early JIA compared to male controls, while IGF-1 levels in girls were comparable between JIA and controls. In early JIA, IGF-1 levels were 12-fold lower in boys relative to girls. In controls, IGF-1 levels correlated with both age and height, while these correlations were lost in boys with early JIA. Conclusion. We report a sex-dependent deficiency in serum IGF-1 in boys with early JIA, which argues for sex-related differences in biological mechanisms involved in the disease pathogenesis.

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