To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Unexpected Fat Distributi… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Unexpected Fat Distribution in Adolescents With Narcolepsy

Journal article
Authors N. M. Drissi
T. Romu
A. M. Landtblom
A. Szakacs
Tove Hallböök
Niklas Darin
M. Borga
O. D. Leinhard
M. Engstrom
Published in Frontiers in Endocrinology
Volume 9
ISSN 1664-2392
Publication year 2018
Published at Institute of Clinical Sciences, Department of Pediatrics
Language en
Links dx.doi.org/10.3389/fendo.2018.00728
Keywords orexin, hypocretin, brown adipose tissue, visceral adipose tissue, subcutaneous adipose tissue, BMI, brown adipose-tissue, metabolic risk-factors, body-mass index, cold-exposure, visceral fat, hypothalamic-lesions, energy-expenditure, insulin-resistance, genetic ablation, orexin neurons
Subject categories Endocrinology and Diabetes

Abstract

Narcolepsy type 1 is a chronic sleep disorder with significantly higher BMI reported in more than 50% of adolescent patients, putting them at a higher risk for metabolic syndrome in adulthood. Although well-documented, the body fat distribution and mechanisms behind weight gain in narcolepsy are still not fully understood but may be related to the loss of orexin associated with the disease. Orexin has been linked to the regulation of brown adipose tissue (BAT), a metabolically active fat involved in energy homeostasis. Previous studies have used BMI and waist circumference to characterize adipose tissue increases in narcolepsy but none have investigated its specific distribution. Here, we examine adipose tissue distribution in 19 adolescent patients with narcolepsy type 1 and compare them to 17 of their healthy peers using full body magnetic resonance imaging (MRI). In line with previous findings we saw that the narcolepsy patients had more overall fat than the healthy controls, but contrary to our expectations there were no group differences in supraclavicular BAT, suggesting that orexin may have no effect at all on BAT, at least under thermoneutral conditions. Also, in line with previous reports, we observed that patients had more total abdominal adipose tissue (TAAT), however, we found that they had a lower ratio between visceral adipose tissue (VAT) and TAAT indicating a relative increase of subcutaneous abdominal adipose tissue (ASAT). This relationship between VAT and ASAT has been associated with a lower risk for metabolic disease. We conclude that while weight gain in adolescents with narcolepsy matches that of central obesity, the lower VAT ratio may suggest a lower risk of developing metabolic disease.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?