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Fluid and PET biomarkers for amyloid pathology in Alzheimer's disease.

Review article
Authors Ann D Cohen
Susan M Landau
Beth E Snitz
William E Klunk
Kaj Blennow
Henrik Zetterberg
Published in Molecular and cellular neurosciences
Volume 97
Pages 3-17
ISSN 1095-9327
Publication year 2019
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 3-17
Language en
Links dx.doi.org/10.1016/j.mcn.2018.12.00...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Neurochemistry

Abstract

Alzheimer's disease (AD) is characterized by amyloid plaques and tau pathology (neurofibrillary tangles and neuropil threads). Amyloid plaques are primarily composed of aggregated and oligomeric β-amyloid (Aβ) peptides ending at position 42 (Aβ42). The development of fluid and PET biomarkers for Alzheimer's disease (AD), has allowed for detection of Aβ pathology in vivo and marks a major advancement in understanding the role of Aβ in Alzheimer's disease (AD). In the recent National Institute on Aging and Alzheimer's Association (NIA-AA) Research Framework, AD is defined by the underlying pathology as measured in patients during life by biomarkers (Jack et al., 2018), while clinical symptoms are used for staging of the disease. Therefore, sensitive, specific and robust biomarkers to identify brain amyloidosis are central in AD research. Here, we discuss fluid and PET biomarkers for Aβ and their application.

Page Manager: Webmaster|Last update: 9/11/2012
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