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Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage

Journal article
Authors L. P. Matic
M. Jesus Iglesias
M. Vesterlund
M. Lengquist
M. G. Hong
S. Saieed
L. Sanchez-Rivera
M. Berg
A. Razuvaev
M. Kronqvist
K. Lund
K. Caidahl
P. Gillgren
F. Pontén
M. Uhlén
J. M. Schwenk
G. K. Hansson
G. Paulsson-Berne
Erika Fagman
J. Roy
R. Hultgren
Göran Bergström
J. Lehtiö
J. Odeberg
U. Hedin
Published in JACC: Basic to Translational Science
Volume 3
Issue 4
Pages 464-480
ISSN 2452-302X
Publication year 2018
Published at Institute of Clinical Sciences, Department of Radiology
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 464-480
Language en
Links dx.doi.org/10.1016/j.jacbts.2018.04...
Subject categories Clinical Medicine

Abstract

Clinical tools to identify individuals with unstable atherosclerotic lesions are required to improve prevention of myocardial infarction and ischemic stroke. Here, a systems-based analysis of atherosclerotic plaques and plasma from patients undergoing carotid endarterectomy for stroke prevention was used to identify molecular signatures with a causal relationship to disease. Local plasma collected in the lesion proximity following clamping prior to arteriotomy was profiled together with matched peripheral plasma. This translational workflow identified biliverdin reductase B as a novel marker of intraplaque hemorrhage and unstable carotid atherosclerosis, which should be investigated as a potential predictive biomarker for cardiovascular events in larger cohorts.

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