To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Novel Multiomics Profilin… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage

Journal article
Authors L. P. Matic
M. Jesus Iglesias
M. Vesterlund
M. Lengquist
M. G. Hong
S. Saieed
L. Sanchez-Rivera
M. Berg
A. Razuvaev
M. Kronqvist
K. Lund
K. Caidahl
P. Gillgren
F. Pontén
M. Uhlén
J. M. Schwenk
G. K. Hansson
G. Paulsson-Berne
Erika Fagman
J. Roy
R. Hultgren
Göran Bergström
J. Lehtiö
J. Odeberg
U. Hedin
Published in JACC: Basic to Translational Science
Volume 3
Issue 4
Pages 464-480
ISSN 2452-302X
Publication year 2018
Published at Institute of Clinical Sciences, Department of Radiology
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 464-480
Language en
Subject categories Clinical Medicine


Clinical tools to identify individuals with unstable atherosclerotic lesions are required to improve prevention of myocardial infarction and ischemic stroke. Here, a systems-based analysis of atherosclerotic plaques and plasma from patients undergoing carotid endarterectomy for stroke prevention was used to identify molecular signatures with a causal relationship to disease. Local plasma collected in the lesion proximity following clamping prior to arteriotomy was profiled together with matched peripheral plasma. This translational workflow identified biliverdin reductase B as a novel marker of intraplaque hemorrhage and unstable carotid atherosclerosis, which should be investigated as a potential predictive biomarker for cardiovascular events in larger cohorts.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?