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Potentially Malignant Oral Disorders and Cancer Transformation

Review article
Authors Divya Ganesh
P. Sreenivasan
Jenny Öhman
Mats Wallström
P. H. Braz-Silva
Daniel Giglio
Göran Kjeller
Bengt Hasséus
Published in Anticancer Research
Volume 38
Issue 6
Pages 3223-3229
ISSN 0250-7005
Publication year 2018
Published at Institute of Odontology
Institute of Clinical Sciences, Department of Oncology
Pages 3223-3229
Language en
Links dx.doi.org/10.21873/anticanres.1258...
Keywords Potentially malignant oral disorders, oral cancer, cancer transformation, review, discoid lupus-erythematosus, of-the-literature, proliferative verrucous, leukoplakia, squamous-cell carcinoma, epidermolysis-bullosa, lichen-planus, actinic cheilitis, dyskeratosis-congenita, clinical, management, submucous fibrosis
Subject categories Cancer and Oncology

Abstract

Cancer in the oral cavity is often preceded by precursor lesions. Nine oral mucosal disorders are known to have an increased risk of malignant transformation. The etiology varies from disorders caused by exogenous factors such as tobacco and autoimmune inflammation to idiopathic or inherited genetic aberrations. In this review, these potentially malignant disorders (PMDs) are described regarding clinical presentation and histopathological architecture. Special attention is paid to the underlying etiologies of PMDs and the potential pathways leading to cancer. The clinical perspective focuses on the importance of accurate and timely diagnosis.

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