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The myth of the immature barrier systems in the developing brain: role in perinatal brain injury

Journal article
Authors Carina Mallard
C. Joakim Ek
Z. S. Vexler
Published in Journal of Physiology-London
Volume 596
Issue 23
Pages 5655-5664
ISSN 0022-3751
Publication year 2018
Published at Institute of Neuroscience and Physiology, Department of Physiology
Pages 5655-5664
Language en
Links dx.doi.org/10.1113/jp274938
Keywords blood-brain barrier, choroid plexus, ischemia, inflammation, development, blood-csf barrier, cerebral-cortex, choroid-plexus, developmental-changes, tight junctions, sonic hedgehog, rat model, expression, hypoxia, fetal
Subject categories Neurophysiology

Abstract

Central nervous system homeostasis is maintained by cellular barriers that protect the brain from external environmental changes and protect the CNS from harmful molecules and pathogens in the blood. Historically, for many years these barriers were thought of as immature, with limited functions, during brain development. In this review, we will present advances in the understanding of the barrier systems during development and evidence to show that in fact the barriers serve many important neurodevelopmental functions and that fetal and newborn brains are well protected. We will also discuss how ischaemic injury or systemic inflammation may breach the integrity of the barriers in the developing brain.

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