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Degree of differentiation of cutaneous squamous cell carcinoma: a comparison between a Swedish cohort of organ transplant recipients and immunocompetent patients.

Journal article
Authors Caroline Stenman
Helena Gonzalez
Martin Gillstedt
Göran Dellgren
Bengt Hasséus
Erik Holmberg
Helena Rexius
Jenny Öhman
John Paoli
Published in Dermatology practical & conceptual
Volume 8
Issue 4
Pages 330-336
ISSN 2160-9381
Publication year 2018
Published at Institute of Odontology
Institute of Clinical Sciences, Department of Dermatology and Venereology
Institute of Clinical Sciences, Department of Oncology
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 330-336
Language en
Links dx.doi.org/10.5826/dpc.0804a18
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Dermatology and Venereal Diseases

Abstract

Organ transplant recipients (OTRs) have a very high risk of developing cutaneous squamous cell carcinoma (cSCC). Immunosuppressed OTRs may have a higher proportion of poorly differentiated cSCC than non-OTRs.The aim of this study was to investigate the degree of differentiation of cSCCs in OTRs compared with immunocompetent individuals.Data from the Swedish Cancer Registry were crosschecked with data from the Transplant registry of the Transplant Institute at Sahlgrenska University Hospital in Gothenburg, Sweden. All OTRs with a diagnosis of cSCC, basosquamous carcinoma, and/or cSCC in situ established at the Department of Dermatology, Sahlgrenska University Hospital, during 2002-2015 were included. The control group consisted of non-OTRs with the same diagnoses during the same time period.During 2002-2015, 82 OTRs diagnosed with 515 tumors and 883 non-OTRs with 1,247 tumors were included. OTRs developed 0.47 tumors/year vs 0.10 tumors/year for non-OTRs, but no significant differences were observed in the degree of tumor differentiation of invasive cSCCs between OTRs and non-OTRs (P = 0.4). The distribution of poorly, moderately, and well-differentiated invasive cSCCs among OTRs and non-OTRs were 8.5% vs 12.5%, 22.1% vs 29.9%, and 69.4% vs 57.6%, respectively.OTRs do not develop a higher proportion of poorly differentiated cSCCs than non-OTRs.

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