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Composition, structure and function of the eukaryotic flagellum distal tip

Review article
Authors Jacob Croft
Davide Zabeo
Radhika Subramanian
Johanna L Höög
Published in Essays in biochemistry
Volume 62
Issue 6
Pages 815-828
ISSN 1744-1358
Publication year 2018
Published at Department of Chemistry and Molecular Biology
Pages 815-828
Language en
Subject categories Structural Biology, Cell Biology, Cell biology, Morphology


Cilia and flagella are long extensions commonly found on the surface of eukaryotic cells. In fact, most human cells have a flagellum, and failure to correctly form cilia leads to a spectrum of diseases gathered under the name 'ciliopathies'. The cilium distal tip is where it grows and signals. Yet, out of the flagellar regions, the distal tip is probably the least intensively studied. In this review, we will summarise the current knowledge on the diverse flagellar tip structures, the dynamicity and signalling that occurs here and the proteins localising to this important cellular region.

Page Manager: Webmaster|Last update: 9/11/2012

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