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The diagnostic value of GerdQ in subjects with atypical symptoms of gastro-esophageal reflux disease.

Journal article
Authors E. Norder Grusell
Ann-Christine Mjörnheim
Caterina Finizia
Magnus Ruth
Henrik Bergquist
Published in Scandinavian journal of gastroenterology
Volume 53
Issue 10-11
Pages 1165-70
ISSN 1502-7708
Publication year 2018
Published at
Pages 1165-70
Language en
Links dx.doi.org/10.1080/00365521.2018.15...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Otorhinolaryngology

Abstract

Symptoms are essential in the clinical diagnosis of gastro-esophageal reflux disease (GERD). Questionnaires such as GerdQ have been developed as diagnostic aids. GerdQ has been thoroughly validated in well-characterized GERD patients, but has not yet been fully evaluated in a population that includes subjects with atypical symptoms.To evaluate GerdQ in a population with typical and/or atypical symptoms of GERD, defined by 24-h pH monitoring. The secondary aim was to investigate the outcome of GerdQ depending on the response to proton pump inhibitor (PPI) treatment.The study included 646 subjects referred for 24-h pH monitoring due to a clinical suspicion of GERD. All subjects completed GerdQ before performing a 24-h pH monitoring.In total, 377 (58%) subjects were diagnosed with GERD based on symptoms and 24-h pH monitoring (GERDpH). Of these, 46% had atypical main symptoms. Overall, GerdQ (at cut-off 8) predicted GERDpH with a sensitivity and specificity of 62% and 74%, respectively. A high specificity but poor sensitivity for diagnosis of GERDpH was found for atypical main symptoms such as cough, dysphagia and globus. GerdQ had a relatively high sensitivity and specificity in predicting PPI response and a PPV of 99% at cut-off 8.GerdQ has a diagnostic value in an unselected population presenting with typical and/or atypical symptoms of GERD, but a low sensitivity for diagnosis of GERDpH was found in subjects with predominant symptoms such as cough, dysphagia and globus.

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