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Longitudinal birth cohort study found that a significant proportion of children had abnormal metabolic profiles and insulin resistance at 6 years of age.

Journal article
Authors Emma Kjellberg
Josefine Roswall
Stefan Bergman
Gerd Almqvist-Tangen
Bernt Alm
Jovanna Dahlgren
Published in Acta paediatrica (Oslo, Norway : 1992)
Volume 108
Issue 3
Pages 486-492
ISSN 1651-2227
Publication year 2019
Published at Institute of Medicine, Department of Public Health and Community Medicine
Institute of Clinical Sciences, Department of Pediatrics
Pages 486-492
Language en
Keywords metabola syndromet, insulin resistens, barn fetma, HDL cholesterol, triglycerider
Subject categories Computational linguistics, Pediatrics


Metabolic syndrome represents a cluster of risk factors for cardiovascular disease, and we investigated whether otherwise healthy 6-year-olds showed metabolic alterations.This study followed up a representative Swedish population-based cohort of full-term infants recruited on the maternity ward at Hallands Hospital Halmstad, Sweden, from 2008 to 2011. They were examined at a mean of 6.6 years of age (range 6.5-6.9) using various measures for signs of metabolic syndrome.One key measure showed that 55 (26%) of the 212 children had one or more risk factors for metabolic syndrome requiring action. The 37 who were obese (3%) or overweight (14%) were significantly more likely to be insulin resistant than the normal weight group (28% versus 5%, p < 0.001) and have high triglycerides (8% versus 0%, p < 0.001). Children with high waist circumferences had higher systolic (p = 0.01) and diastolic (p = 0.02) blood pressure than those with normal waist circumferences. Waist circumference identified children at high risk of metabolic syndrome better than body mass index.A significant percentage of 6-year-old children showed abnormal metabolic profiles, including insulin resistance, which increased their risk of cardiovascular disease. Waist circumference was a stronger marker for metabolic alterations than body mass index.

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