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Impact of Cardiopulmonary Bypass Flow on Renal Oxygenation in Patients Undergoing Cardiac Operations

Journal article
Authors Lukas Lannemyr
Gudrun Bragadottir
Anders Hjärpe
Bengt Redfors
Sven-Erik Ricksten
Published in The Annals of thoracic surgery
Volume 107
Issue 2
Pages 505-511
ISSN 1552-6259
Publication year 2019
Published at Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
Institute of Clinical Sciences
Pages 505-511
Language en
Subject categories Anesthesiology and Intensive Care


Cardiac surgery with cardiopulmonary bypass (CPB) is associated with acute kidney injury, and the risk increases with low oxygen delivery during CPB. We hypothesized that renal oxygenation could be improved at higher than normal CPB flow rates.After ethical approval and informed consent, 17 patients with normal serum creatinine undergoing normothermic CPB were included and received pulmonary artery and renal vein catheters after anesthesia induction for measurements of systemic and renal variables. Renal oxygen extraction (RO2Ex), a direct measure of the renal oxygen delivery /renal oxygen consumption ratio, and renal filtration fraction were measured, the latter by renal extraction of 51chromium-EDTA. After start of CPB and aortic cross-clamp, the pump flow rate was randomly varied between 2.4, 2.7 and 3.0 l·min-1·m-2 and measurements were made after 10 minutes at each flow rate.RO2Ex increased by 30% at a flow rate of 2.4 l·min-1·m-2 vs. pre-CPB (p<0.05). At a flow rate of 2.7 and 3.0 l·min-1·m-2, RO2Ex was 12% (p<0.05) and 23% (p<0.01) lower, respectively, compared to 2.4 l·min-1·m-2. This corresponds to a 14% and 30% improvement, respectively, of the renal oxygen supply/demand relationship. Filtration fraction was not affected by changes in flow rate, indicating that the glomerular filtration rate increased in proportion to the increase in renal perfusion.The impaired renal oxygenation seen during CPB is ameliorated by an increase in CPB flow rate. Thus, one way to protect the kidneys, during CPB, could be to use a higher flow rate than the one traditionally used.

Page Manager: Webmaster|Last update: 9/11/2012

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