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Proteomics of the acid-soluble fraction of whole and major gland saliva in burning mouth syndrome patients

Journal article
Authors T. Cabras
B. Manconi
M. Castagnola
M. T. Sanna
M. Arba
Shikha Acharya
Jörgen Ekström
Anette Carlén
I. Messana
Published in Archives of Oral Biology
Volume 98
Pages 148-155
ISSN 0003-9969
Publication year 2019
Published at Institute of Odontology
Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 148-155
Language en
Keywords Burning mouth syndrome, Cystatin SN, Proteomics, saliva, Top-down
Subject categories Dentistry


Objective: In the present study the salivary proteome of burning mouth syndrome patients and healthy subjects was characterized by a top-down proteomic approach and compared to highlight possible qualitative and quantitative differences that may give suggestions about the causes of this pathology which are still unknown. Materials and methods: Resting and stimulated whole saliva, stimulated parotid and submandibular/sublingual saliva samples were collected from burning mouth syndrome patients (n = 16) and age- and gender-matched healthy subjects (n = 14). An equal volume of 0.2% trifluoroacetic acid was added to each sample immediately after collection and the supernatants were analysed by liquid chromatography coupled to electrospray-ionisation mass spectrometry. Proteins and peptides were quantified using a label-free approach measuring the extracted ion current peak areas of the main salivary proteins and peptides. Results: The quantitation of the main salivary proteins and peptides revealed a higher concentration of cystatin SN in resting saliva of burning mouth syndrome patients with respect to healthy controls and no other conspicuous changes. Conclusions: The reported data showed that the salivary protein profile was not affected, in composition and relative abundance, by the burning mouth syndrome, except for the cystatin SN, a protein up-regulated in several pathological conditions, that might be considered potentially indicative of the disease. © 2018

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