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Cholera

Review article
Authors John D. Clemens
G. Balakrish Nair
Tahmeed Ahmed
Firdausi Qadri
Jan Holmgren
Published in The Lancet
Volume 390
Pages 1539-1549
ISSN 0140-6736
Publication year 2017
Published at Institute of Biomedicine
Pages 1539-1549
Language en
Links doi.org/10.1016/S0140-6736(17)30559...
Subject categories Public Health, Global Health, Social Medicine and Epidemiology, Microbiology in the medical area

Abstract

© 2017 Elsevier Ltd Cholera is an acute, watery diarrhoeal disease caused by Vibrio cholerae of the O1 or O139 serogroups. In the past two centuries, cholera has emerged and spread from the Ganges Delta six times and from Indonesia once to cause global pandemics. Rational approaches to the case management of cholera with oral and intravenous rehydration therapy have reduced the case fatality of cholera from more than 50% to much less than 1%. Despite improvements in water quality, sanitation, and hygiene, as well as in the clinical treatment of cholera, the disease is still estimated to cause about 100 000 deaths every year. Most deaths occur in cholera-endemic settings, and virtually all deaths occur in developing countries. Contemporary understanding of immune protection against cholera, which results from local intestinal immunity, has yielded safe and protective orally administered cholera vaccines that are now globally stockpiled for use in the control of both epidemic and endemic cholera.

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