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Allergic contact dermatitis to hydroperoxides of limonene and dose-response relationship - a repeated open application test (ROAT) study.

Journal article
Authors Niels H Bennike
Lina Palangi
Johanna Bråred Christensson
Ulrika Nilsson
Claus Zachariae
Jeanne D Johansen
Lina Hagvall
Published in Contact dermatitis
Volume 80
Issue 4
Pages 208-216
ISSN 1600-0536
Publication year 2019
Published at Institute of Clinical Sciences, Department of Dermatology and Venereology
Department of Chemistry and Molecular Biology
Pages 208-216
Language en
Links dx.doi.org/10.1111/cod.13168
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Dermatology and Venereal Diseases

Abstract

Contact allergy to oxidized limonene, with hydroperoxides of limonene (Lim-OOHs) as main allergens, is common. However, high proportions of weak positive and doubtful patch test reactions have been reported.To determine clinical relevance, elicitation threshold, and dose-response relationship of Lim-OOHs in individuals with a positive or doubtful patch test to standard Lim-OOHs 0.3% pet.A multicentre 3-week double-blinded vehicle-controlled repeated open application test (ROAT) study with a simulated fine fragrance containing Lim-OOHs at 1260 ppm, 420 ppm, and 140 ppm, equal to a dose/area per application of Lim-OOHs of 3.0 μg/cm2 , 0.99 μg/cm2 , and 0.33 μg/cm2 .Among 11 subjects allergic to Lim-OOHs, 11 (100%), 7 (64%), and 3 (27%), respectively, reacted to the applied doses. No reactions were seen in 17 healthy controls exposed to the highest dose. This difference in reactivity was statistically significant (P<0.0001). Among 13 subjects with a doubtful patch test to Lim-OOHs, two (15%) had a positive ROAT to the highest Lim-OOHs dose applied (P=0.36 compared to controls).Contact allergy to Lim-OOHs is of clinical relevance in patients with a positive patch test. A doubtful patch test to Lim-OOHs 0.3% pet. can be of clinical relevance. This article is protected by copyright. All rights reserved.

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