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Determination of T Follicular Helper Cell Fate by Dendritic Cells

Journal article
Authors J. K. Krishnaswamy
Samuel Alsén
Ulf Yrlid
S. C. Eisenbarth
A. Williams
Published in Frontiers in Immunology
Volume 9
ISSN 1664-3224
Publication year 2018
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Language en
Links dx.doi.org/10.3389/fimmu.2018.02169
Keywords dendritic cell, Tfh cell, DC subset, DC migration, humoral response, vaccine, humoral immune-responses, antigen-presenting cells, draining, lymph-nodes, in-vivo, b-cell, langerhans cells, cutting edge, cd28-deficient mice, chemokine receptor, antibody-responses, Immunology
Subject categories Clinical immunology

Abstract

T follicular helper (Tfh) cells are a specialized subset of CD4(+) T cells that collaborate with B cells to promote and regulate humoral responses. Unlike other CD4(+) effector lineages, Tfh cells require interactions with both dendritic cells (DCs) and B cells to complete their differentiation. While numerous studies have assessed the potential of different DC subsets to support Tfh priming, the conclusions of these studies depend heavily on the model and method of immunization used. We propose that the location of different DC subsets within the lymph node (LN) and their access to antigen determine their potency in Tfh priming. Finally, we provide a three-step model that accounts for the ability of multiple DC subsets and related lineages to support the Tfh differentiation program.

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