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A sequence environment modulates the impact of methylation on the torsional rigidity of DNA

Journal article
Authors Johanna Hörberg
Anna Reymer
Published in Chemical Communications
Volume 54
Issue 84
Pages 11885-11888
ISSN 1359-7345
Publication year 2018
Published at Department of Chemistry and Molecular Biology
Pages 11885-11888
Language en
Links dx.doi.org/10.1039/c8cc06550k
Keywords cytosine methylation, b-DNA, insights, Chemistry
Subject categories Biochemistry and Molecular Biology

Abstract

We describe a potential molecular mechanism explaining how DNA methylation contributes to biological regulation. Using molecular dynamics together with a new torsional restraint, we identify the impact of methylation on DNA response to torsional stress. We observe that, depending on the sequence, DNA methylation hinders overwinding or underwinding molecular transitions.

Page Manager: Webmaster|Last update: 9/11/2012
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