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Renal swelling indicates renal damage in infants with their first urinary tract infection

Journal article
Authors Yvonne Simrén
Sindri Valdimarsson
Eira Stokland
Kerstin M Lagerstrand
Rune Sixt
Published in Acta Paediatrica
Volume 107
Issue 11
Pages 2004-2010
ISSN 0803-5253
Publication year 2018
Published at Institute of Clinical Sciences, Department of Radiation Physics
Institute of Clinical Sciences, Department of Pediatrics
Institute of Clinical Sciences, Department of Radiology
Pages 2004-2010
Language en
Keywords Renal damage, Renal length, Renal swelling, Ultrasound, Urinary tract infection, acute pyelonephritis, tc-99m-dmsa scintigraphy, young-children, ultrasonography, guidelines, childhood, reflux, sonography, ultrasound, diagnosis, Pediatrics, okland e, 1994, british medical journal, v309, p235
Subject categories Pediatrics


Aim: We used ultrasound to evaluate renal swelling as a predictor of acute and permanent renal damage in infants with their first urinary tract infection (UTI). Methods: The cohort at the Queen Silvia Children's Hospital, Gothenburg, Sweden, comprised 101 infants with their first UTI at a mean age of 3.9 +/- 3.0 months. Acute and follow-up ultrasounds were carried out a few days and one month after treatment started, and a (99m)technetium dimercaptosuccinic acid (DMSA) scan was carried out after one month and after a year if the first scan was abnormal. Results: The acute ultrasounds showed that renal length and volume, calculated as standard deviation scores (SDS), were 1.39 +/- 1.43 SDS and 1.30 +/- 1.08 SDS. We found that 52% of the one-month DMSA scans and 25% of the one-year DMSA scans were abnormal. Renal length (p = 0.0026) and initial volume (p = 0.0005) on the ultrasound predicted acute renal damage at the one-month DMSA scan and initial renal length (p = 0.030) predicted permanent renal damage at the one-year DMSA scan. Conclusion: Renal swelling was associated with renal damage. Although the diagnostic performance compared with the DMSA scan was weak, renal swelling may help clinicians to make decisions about further investigations and follow-ups of infants with UTIs.

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