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A 3-year longitudinal study of skeletal effects and growth in children after kidney transplantation

Journal article
Authors Diana Swolin-Eide
Sverker Hansson
P. Magnusson
Published in Pediatric Transplantation
Volume 22
Issue 6
ISSN 1397-3142
Publication year 2018
Published at Institute of Clinical Sciences, Department of Pediatrics
Language en
Links dx.doi.org/10.1111/petr.13253
Keywords body composition, bone markers, bone mineral density, dual-energy X-ray absorptiometry, growth, pediatric kidney transplantation, bone-mineral density, solid-organ transplantation, chronic-renal-failure, x-ray absorptiometry, alkaline-phosphatase, healthy-children, turnover markers, risk-factors, laser dxl, disease, Pediatrics, Transplantation, hwartz gj, 1976, pediatrics, v58, p259
Subject categories Pediatrics, Transplantation surgery

Abstract

This prospective study investigated growth and skeletal development for 3years after kidney transplantation in pediatric patients, 3.4-15.0years of age. Growth, BMD, bone resorption markers (CTX and TRACP5b), bone formation markers (PINP, ALP, and osteocalcin), PTH, and vitamin D were assessed at start, 3, 12, and 36months after transplantation. Median GFR was 63 (range 37-96) mL/min/1.73m(2) after 3years. The median height SDS increased from -1.7 to -1.1, and median BMI SDS increased from -0.1 to 0.6 over 3years, which shows that transplantation had a favorable outcome on growth. Fat mass increased after transplantation at all time points, whereas lean mass increased after 1year and 3years. Total BMC increased at all time points. No changes were observed for total BMD. Bone resorption markers decreased initially after 3months and remained stable throughout the study, whereas the bone formation markers decreased initially, but successively increased over the study period. In conclusion, this study demonstrates that height SDS and BMI SDS increased, along with the increased formation markers that reveal a positive bone acquisition after kidney transplantation, which was reflected by the significant increase in total body BMC.

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