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Contact allergy to oxidized geraniol among Swedish dermatitis patients-A multicentre study by the Swedish Contact Dermatitis Research Group

Journal article
Authors Lina Hagvall
M. Bruze
M. Engfeldt
M. Isaksson
M. Lindberg
K. Ryberg
B. Stenberg
C. Svedman
A. T. Karlberg
Johanna Bråred Christensson
Published in Contact Dermatitis
Volume 79
Issue 4
Pages 232-238
ISSN 0105-1873
Publication year 2018
Published at Institute of Clinical Sciences, Department of Dermatology and Venereology
Department of Chemistry and Molecular Biology
Pages 232-238
Language en
Keywords allergic contact dermatitis, autoxidation, fragrance contact allergy, fragrance mix I, geraniol, patch, patch test reactions, lavender oil, air exposure, skin sensitization, oxidation-products, linalyl acetate, fragrances, limonene, hydroperoxides, quantification, Allergy, Dermatology
Subject categories Dermatology and Venereal Diseases, Respiratory Medicine and Allergy


Background: Geraniol is a widely used fragrance terpene, and is included in fragrance mix I. Geraniol is prone to autoxidation, forming the skin sensitizers geranial, neral, and geraniol-7-hydroperoxide. Oxidized geraniol has previously been patch tested in 1 clinic, giving 1% to 4.6% positive reactions in consecutive patients when tested at 2% to 11%. Aim: To compare test reactions to pure and oxidized geraniol, to compare 2 different test concentrations of oxidized geraniol and to investigate the pattern of concomitant reactions to fragrance markers of the baseline series in a multicentre setting. Methods: One thousand four hundred and seventy-six consecutive patients referred for patch testing were patch tested with geraniol 6% pet. and oxidized geraniol 6% and 11% pet. Results: Pure geraniol 6% pet., oxidized geraniol 6% pet. and oxidized geraniol 11% pet. gave 1%, 3% and 8% positive patch test reactions and 0.7%, 3% and 5% doubtful reactions, respectively. Approximately 50% of the patients with doubtful reactions to oxidized geraniol 6% pet. had positive reactions to oxidized geraniol 11% pet. Conclusions: Oxidized geraniol 11% pet. provides better detection than oxidized geraniol 6% pet. As most patients reacted only to oxidized geraniol, it is important to explore further whether oxidized geraniol should be included in a baseline patch test series.

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