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Direct detection of Exophiala and Scedosporium species in sputa of patients with cystic fibrosis

Journal article
Authors M. Chen
Nahid Kondori
S. W. Deng
Ahgg van den Ende
M. Lackner
W. Q. Liao
G. S. de Hoog
Published in Medical Mycology
Volume 56
Issue 6
Pages 695-702
ISSN 1369-3786
Publication year 2018
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages 695-702
Language en
Keywords Exophiala dermatitidis, Scedosporium, cystic fibrosis, sputum, molecular epidemiology, filamentous fungi, culture-medium, dermatitidis, apiospermum, prevalence, pseudallescheria, amplification, infection, complex, Infectious Diseases, Mycology, Veterinary Sciences
Subject categories Infectious Medicine


Detection of species of Exophiala and Scedosporium in the respiratory tracts of cystic fibrosis (CF) patients remains controversial because of highly variable results. The results of our study suggested a significantly higher prevalence and more complex colonization than previously estimated. Approximately 17% (27/162) of clinical sputum samples were found to be positive for Exophiala dermatitidis and 30% (49/162) were positive for Scedosporium apiospermum / S. boydii species complex determined by reverse line blot (RLB) hybridization. In contrast, only 14.2% (23/162) and 1.2% ( 2 / 1 62) of clinical sputa were positive for E. dermatitidis and S. apiospermum / S. boydii species complex when tested by culture, respectively. Molecular detection methods, such as loop-mediated isothermal amplification (LAMP) or reverse line blot (RLB) hybridization, have the potential to become powerful alternatives to selective culture, providing a more realistic understanding on the prevalence of E. dermatitidis and S. apiospermum / S. boydii species complex in the respiratory tract of CF patients.

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