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Alzheimer-associated cerebrospinal fluid fragments of neurogranin are generated by Calpain-1 and prolyl endopeptidase

Journal article
Authors Bruno Becker
Faisal Hayat Nazir
Gunnar Brinkmalm
Elena Camporesi
Hlin Kvartsberg
Erik Portelius
Martina Boström
Marie Kalm
Kina Höglund
Maria Olsson
Henrik Zetterberg
Kaj Blennow
Published in Molecular Neurodegeneration
Volume 13
ISSN 1750-1326
Publication year 2018
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Institute of Neuroscience and Physiology, Department of Pharmacology
Language en
Links dx.doi.org/10.1186/s13024-018-0279-...
Subject categories Psychiatry, Neurochemistry

Abstract

Background: Neurogranin (Ng) is a small 7.6 kDa postsynaptic protein that has been detected at Methods: Fluorigenic quenched FRET probes containing sequences of Ng were utilized to identify Ng Results: Human Calpain-1 and prolyl endopeptidase were identified as the candidate enzymes involved

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