To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

A mechanistic linkage bet… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

A mechanistic linkage between oral lichen planus and autoimmune thyroid disease.

Journal article
Authors Jairo Robledo-Sierra
Kerstin Landin-Wilhelmsen
Helena Filipsson Nyström
Robert Eggertsen
Lena Larsson
Amal Dafar
G Warfvinge
Ulf Mattsson
Mats Jontell
Published in Oral diseases
Volume 24
Issue 6
Pages 1001-1011
ISSN 1601-0825
Publication year 2018
Published at Institute of Odontology
Institute of Odontology, Section 1
Institute of Odontology, Section 2
Institute of Medicine, Department of Public Health and Community Medicine
Institute of Medicine
Pages 1001-1011
Language en
Subject categories Clinical Medicine, Endocrinology and Diabetes


To determine the levels of antithyroid antibodies and thyroid hormones in the sera of patients with oral lichen planus (OLP), and to quantify the expression of thyroid proteins in OLP lesions.Venous blood samples were drawn from 110 patients with OLP who had no history of thyroid disease or levothyroxine supplementation (OLP+/LT4 -). A random population sample of 657 healthy subjects was used as the control group. Two additional groups were used as comparators. Immunohistochemical and qPCR analyses were performed on tissue specimens collected from the patients with OLP and thyroid disease and healthy subjects.No association was found between the presence of antithyroid antibodies and OLP. More patients in the OLP+/LT4 - group showed high levels of thyroid-stimulating hormone and low levels of free thyroxine than were seen in the control group. Thyroid-stimulating hormone receptor was more highly expressed in the OLP lesions of patients with thyroid disease than in the healthy oral mucosa.A significant number of patients with OLP who are not previously diagnosed with thyroid disease have thyroid parameters that are compatible with hypothyroidism. The expression of thyroid-stimulating hormone receptor in OLP lesions suggests that mechanisms related to autoimmune thyroid disease are involved in the aetiology of OLP.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?