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RIFINs are adhesins implicated in severe Plasmodium falciparum malaria.

Journal article
Authors Suchi Goel
Mia Palmkvist
Kirsten Moll
Nicolas Joannin
Patricia Lara
Reetesh R Akhouri
Nasim Moradi
Karin Öjemalm
Mattias Westman
Davide Angeletti
Hanna Kjellin
Janne Lehtiö
Ola Blixt
Lars Ideström
Carl G Gahmberg
Jill R Storry
Annika K Hult
Martin L Olsson
Gunnar von Heijne
IngMarie Nilsson
Mats Wahlgren
Published in Nature medicine
Volume 21
Issue 4
Pages 314-7
ISSN 1546-170X
Publication year 2015
Published at
Pages 314-7
Language en
Links dx.doi.org/10.1038/nm.3812
www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords ABO Blood-Group System, Animals, Antigens, Protozoan, physiology, CHO Cells, Cricetinae, Cricetulus, Dogs, Drosophila, Erythrocytes, parasitology, Escherichia coli, metabolism, Fluorescent Antibody Technique, Indirect, Humans, Immunoglobulin G, immunology, Malaria, Falciparum, metabolism, Male, Microcirculation, Microscopy, Confocal, Microsomes, metabolism, Pancreas, parasitology, Plasmodium falciparum, metabolism, Protein Multimerization, Protozoan Proteins, physiology, Rats, Rats, Sprague-Dawley, Sequence Analysis, RNA, Transfection
Subject categories Cell biology

Abstract

Rosetting is a virulent Plasmodium falciparum phenomenon associated with severe malaria. Here we demonstrate that P. falciparum-encoded repetitive interspersed families of polypeptides (RIFINs) are expressed on the surface of infected red blood cells (iRBCs), where they bind to RBCs--preferentially of blood group A--to form large rosettes and mediate microvascular binding of iRBCs. We suggest that RIFINs have a fundamental role in the development of severe malaria and thereby contribute to the varying global distribution of ABO blood groups in the human population.

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