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Defining B cell immunodominance to viruses.

Journal article
Authors Davide Angeletti
James S Gibbs
Matthew Angel
Ivan Kosik
Heather D Hickman
Gregory M Frank
Suman R Das
Adam K Wheatley
Madhu Prabhakaran
David J Leggat
Adrian B McDermott
Jonathan W Yewdell
Published in Nature immunology
Volume 18
Issue 4
Pages 456-463
ISSN 1529-2916
Publication year 2017
Published at
Pages 456-463
Language en
Keywords Animals, Antibodies, Viral, blood, immunology, Antigens, Viral, chemistry, immunology, B-Lymphocytes, immunology, metabolism, CD4-Positive T-Lymphocytes, immunology, metabolism, Genetic Background, Hemagglutinin Glycoproteins, Influenza Virus, chemistry, immunology, Host-Pathogen Interactions, genetics, immunology, Immunization, Immunodominant Epitopes, chemistry, immunology, Immunologic Memory, Influenza A virus, immunology, Lymph Nodes, immunology, Mice, Models, Molecular, Orthomyxoviridae Infections, genetics, immunology, Protein Conformation, Virus Diseases, genetics, immunology, virology, Viruses, immunology
Subject categories Immunology in the medical area, Virology


Immunodominance (ID) defines the hierarchical immune response to competing antigens in complex immunogens. Little is known regarding B cell and antibody ID despite its importance in immunity to viruses and other pathogens. We show that B cells and serum antibodies from inbred mice demonstrate a reproducible ID hierarchy to the five major antigenic sites in the influenza A virus hemagglutinin globular domain. The hierarchy changed as the immune response progressed, and it was dependent on antigen formulation and delivery. Passive antibody transfer and sequential infection experiments demonstrated 'original antigenic suppression', a phenomenon in which antibodies suppress memory responses to the priming antigenic site. Our study provides a template for attaining deeper understanding of antibody ID to viruses and other complex immunogens.

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