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Antibody Immunodominance: The Key to Understanding Influenza Virus Antigenic Drift.

Review article
Authors Meghan O Altman
Davide Angeletti
Jonathan W Yewdell
Published in Viral immunology
Volume 31
Issue 2
Pages 142-149
ISSN 1557-8976
Publication year 2018
Published at
Pages 142-149
Language en
Links dx.doi.org/10.1089/vim.2017.0129
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Immunology in the medical area, Virology

Abstract

Influenza A virus (IAV) imposes a significant socioeconomic burden on humanity. Vaccination is effective in only 60% of individuals, even under optimal circumstances. The difficulty stems from the remarkable ability of IAV to evade existing immunity. IAV's error prone polymerase enables the rapid antigenic evolution of the two virion surface glycoproteins, neuraminidase and hemagglutinin (HA). Since the most potent antibodies (Abs) at neutralizing viral infectivity are directed the head of the HA, amino acid substitutions in this region enable IAV to evade Ab-based immunity. Here, we review recent progress in understanding how immunodominance, the tendency of the immune system to respond to foreign immunogens in a hierarchical manner, shapes IAV evolution.

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