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Understanding and Manipulating Viral Immunity: Antibody Immunodominance Enters Center Stage.

Review article
Authors Davide Angeletti
Jonathan W Yewdell
Published in Trends in immunology
Volume 39
Issue 7
Pages 549-561
ISSN 1471-4981
Publication year 2018
Published at
Pages 549-561
Language en
Links dx.doi.org/10.1016/j.it.2018.04.008
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Immunology in the medical area

Abstract

Adaptive immune responses against antigenically variable viruses and cellular pathogens are efficient in many cases, but largely limited to the infecting or immunizing strain. A major factor that limits immunity is immunodominance (ID), the hierarchical focusing of adaptive immune responses on a subset of antigenic determinants. While CD8+ T cell ID has been extensively studied, studies of basic mechanisms of B cell ID are limited, despite the importance of antibodies (Abs) for durable protection against pathogens. Here, we review recent progress in understanding the basic rules and mechanisms of B cell ID, compare B and CD8+ T cell ID, and outline challenges to overcoming ID to develop Ab-based 'universal' vaccines for influenza A and other highly variable viruses.

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