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Maternal androgen excess and obesity induce sexually dimorphic anxiety-like behavior in the offspring

Journal article
Authors M. Manti
R. Fornes
X. J. Qi
E. Folmerz
A. L. Hirschberg
T. D. Barbosa
M. Maliqueo
Anna Benrick
E. Stener-Victorin
Published in Faseb Journal
Volume 32
Issue 8
Pages 4158-4171
ISSN 0892-6638
Publication year 2018
Published at Institute of Neuroscience and Physiology, Department of Physiology
Pages 4158-4171
Language en
Links dx.doi.org/10.1096/fj.201701263RR
Keywords dihydrotestosterone, high-fat-high-sucrose, amygdala, polycystic ovary syndrome, polycystic-ovary-syndrome, high-fat diet, long-term health, psychiatric-disorders, reduces anxiety, rhesus-monkeys, anti-anxiety, stress, brain, testosterone, Biochemistry & Molecular Biology, Life Sciences & Biomedicine - Other, Topics, Cell Biology
Subject categories Cell Biology, Biochemistry and Molecular Biology

Abstract

Maternal polycystic ovary syndrome (PCOS), a condition associated with hyperandrogenism, is suggested to increase anxiety-like behavior in the offspring. Because PCOS is closely linked to obesity, we investigated the impact of an adverse hormonal or metabolic maternal environment and offspring obesity on anxiety in the offspring. The obese PCOS phenotype was induced by chronic high-fat-high-sucrose (HFHS) consumption together with prenatal dihydrotestosterone exposure in mouse dams. Anxiety-like behavior was assessed in adult offspring with the elevated-plus maze and open-field tests. The influence of maternal androgens and maternal and offspring diet on genes implicated in anxiety were analyzed in the amygdala and hypothalamus with real-time PCR (n = 47). Independent of diet, female offspring exposed to maternal androgens were more anxious and displayed up-regulation of adrenoceptor 1B in the amygdala and up-regulation of hypothalamic corticotropin-releasing hormone (Crh). By contrast, male offspring exposed to a HFHS maternal diet had increased anxiety-like behavior and showed up-regulation of epigenetic markers in the amygdala and up-regulation of hypothalamic Crh. Overall, there were substantial sex differences in gene expression in the brain. These findings provide novel insight into how maternal androgens and obesity exert sex-specific effects on behavior and gene expression in the offspring of a PCOS mouse model.Manti, M., Fornes, R., Qi, X., Folmerz, E., Linden Hirschberg, A., de Castro Barbosa, T., Maliqueo, M., Benrick, A., Stener-Victorin, E. Maternal androgen excess and obesity induce sexually dimorphic anxiety-like behavior in the offspring.

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