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Circulating tumor cells mirror bone metastatic phenotype in prostate cancer

Journal article
Authors Andreas Josefsson
Karin Larsson
Marianne Månsson
Jens Björkman
Eva Rohlova
Daniel Åhs
Helena Brisby
Jan-Erik Damber
Karin Welén
Published in Oncotarget
Volume 9
Pages 29403-29413
Publication year 2018
Published at Sahlgrenska Cancer Center
Institute of Clinical Sciences, Department of Urology
Institute of Clinical Sciences, Department of Orthopaedics
Pages 29403-29413
Language en
Links doi.org/10.18632/oncotarget.25634
Keywords Circulating tumor cells, Liquid biopsies, Skeletal metastases of prostate cancer
Subject categories Medical Biotechnology

Abstract

© Josefsson A et al. Circulating tumor cells (CTCs) are promising biomarkers in prostate cancer (PC) because they derive from primary tumor and metastatic tissues. In this study, we used quantitative real-time PCR (qPCR) to compare the expression profiles of 41 PC-related genes between paired CTC and spinal column metastasis samples from 22 PC patients that underwent surgery for spinal cord compression. We observed good concordance between the gene expression profiles in the CTC and metastasis samples in most of the PC patients. Expression of nine genes (AGR2, AKR1C3, AR, CDH1, FOLH1, HER2, KRT19, MDK, and SPINK1) showed a significant correlation between the CTC and metastasis samples. Hierarchical clustering analysis showed a similar grouping of PC patients based on the expression of these nine genes in both CTC and metastasis samples. Our findings demonstrate that CTCs mirror gene expression patterns in tissue metastasis samples from PC patients. Although low detection frequency of certain genes is a limitation in CTCs, our results indicate the potential for CTC phenotyping as a tool to improve individualized therapy in metastatic prostate cancer.

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