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Coinfection with Enteric Pathogens in East African Children with Acute Gastroenteritis-Associations and Interpretations

Journal article
Authors Maria Andersson
J. C. Kabayiza
Kristina Elfving
S. Nilsson
M. I. Msellem
A. Martensson
A. Bjorkman
Tomas Bergström
Magnus Lindh
Published in American Journal of Tropical Medicine and Hygiene
Volume 98
Issue 6
Pages 1566-1570
ISSN 0002-9637
Publication year 2018
Published at Institute of Biomedicine, Department of Infectious Medicine
Pages 1566-1570
Language en
Links dx.doi.org/10.4269/ajtmh.17-0473
Keywords enterotoxigenic escherichia-coli, real-time pcr, childhood diarrhea, developing-countries, rwandan children, gems, enteropathogens, multicenter, disease, age, Public, Environmental & Occupational Health, Tropical Medicine
Subject categories Infectious Medicine

Abstract

Enteric coinfections among children in low-income countries are very common, but it is not well known if specific pathogen combinations are associated or have clinical importance. In this analysis, feces samples from children in Rwanda and Zanzibar less than 5 years of age, with (N = 994) or without (N = 324) acute diarrhea, were analyzed by realtime polymerase chain reaction targeting a wide range of pathogens. Associations were investigated by comparing codetection and mono-detection frequencies for all pairwise pathogen combinations. More than one pathogen was detected in 840 samples (65%). A negative association (coinfections being less common than expected from probability) was observed for rotavirus in combination with Shigella, Campylobacter, or norovirus genogroup II, but only in patients, which is statistically expected for agents that independently cause diarrhea. A positive correlation was observed, in both patients and controls, between Ct (threshold cycle) values for certain virulence factor genes in enteropathogenic Escherichia coli (EPEC) (eae and bfpA) and toxin genes in enterotoxigenic E. coli (eltB and estA), allowing estimation of how often these genes were present in the same bacteria. A significant positive association in patients only was observed for Shigella andEPEC-eae, suggesting that this coinfection might interact in a manner that enhances symptoms. Although interaction between pathogens that affect symptoms is rare, this work emphasizes the importance and difference in interpretation of coinfections depending on whether they are positively or negatively associated.

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