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No association of salivary total tau concentration with Alzheimer's disease.

Journal article
Authors Nicholas Ashton
Mark Ide
Michael Schöll
Kaj Blennow
Simon Lovestone
Abdul Hye
Henrik Zetterberg
Published in Neurobiology of aging
Volume 70
Pages 125-127
ISSN 1558-1497
Publication year 2018
Published at Institute of Neuroscience and Physiology
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Wallenberg Centre for Molecular and Translational Medicine
Pages 125-127
Language en
Links dx.doi.org/10.1016/j.neurobiolaging...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Neurology, Psychiatry, Neurosciences

Abstract

There is a need for an accessible biomarker that can complement current cerebrospinal fluid and imaging biomarkers in an accurate and early diagnosis of Alzheimer disease (AD). Saliva is a rich source of potential biomarkers and proteins related to neurodegenerative disorders have been shown to be present in this matrix, including tau. In this study, we quantified salivary total tau (t-tau) concentration in 160 healthy elderly control, 68 mild cognitive impairment, and 53 AD participants using ultrasensitive Single molecule array (Simoa) technology. No median difference in salivary t-tau concentration was found between AD and mild cognitive impairment or healthy elderly control (12.3 ng/L, 9.8 ng/L and 9.6 ng/L, respectively, p = 0.219). In addition, there was no association of salivary t-tau concentration with neurophysiological assessment or structural magnetic resonance imaging. Despite a nominal increase in AD, due to the large overlaps in concentrations between clinical groups, we conclude that salivary t-tau is a suitable biomarker neither for AD nor for cognitive impairment.

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