To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Amyloid-beta, Tau, and Co… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Amyloid-beta, Tau, and Cognition in Cognitively Normal Older Individuals: Examining the Necessity to Adjust for Biomarker Status in Normative Data

Journal article
Authors I. Bos
S. J. B. Vos
W. J. Jansen
R. Vandenberghe
S. Gabel
A. Estanga
M. Ecay-Torres
J. Tomassen
A. den Braber
A. Lleo
I. Sala
Anders Wallin
Petronella Kettunen
J. L. Molinuevo
L. Rami
G. Chetelat
V. de la Sayette
M. Tsolaki
Y. Freund-Levi
P. Johannsen
G. P. Novak
I. Ramakers
F. R. Verhey
P. J. Visser
Initia Alzheimers Dis Neuroimaging
Published in Frontiers in Aging Neuroscience
Volume 10
ISSN 1663-4365
Publication year 2018
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Language en
Keywords Alzheimer's disease, amyloid-beta, tau, cognition, neuropsychological examination, normative data, preclinical alzheimers-disease, cerebrospinal-fluid biomarkers, diagnostic-criteria, international workshop, dementia, impairment, adults, age, decline, participants, Geriatrics & Gerontology, Neurosciences & Neurology, lstein mf, 1975, journal of psychiatric research, v12, p189, khann g, 1984, neurology, v34, p939
Subject categories Neurosciences


We investigated whether amyloid-beta (A beta) and tau affected cognition in cognitively normal (CN) individuals, and whether norms for neuropsychological tests based on biomarker-negative individuals would improve early detection of dementia. We included 907 CN individuals from 8 European cohorts and from the Alzheimer's disease Neuroimaging Initiative. All individuals were aged above 40, had A beta status and neuropsychological data available. Linear mixed models were used to assess the associations of Ali and tau with five neuropsychological tests assessing memory (immediate and delayed recall of Auditory Verbal Learning Test, AVLT), verbal fluency (Verbal Fluency Test, VFT), attention and executive functioning (Trail Making Test, TMT, part A and B). All test except the VFT were associated with status and this influence was augmented by age. We found no influence of tau on any of the cognitive tests. For the AVLT Immediate and Delayed recall and the TMT part A and B, we calculated norms in individuals without A beta pathology (A beta- norms), which we validated in an independent memory-clinic cohort by comparing their predictive accuracy to published norms. For memory tests, the A beta- norms rightfully identified an additional group of individuals at risk of dementia. For non-memory test we found no difference. We confirmed the relationship between Ao and cognition in cognitively normal individuals. The Af3- norms for memory tests in combination with published norms improve prognostic accuracy of dementia.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?