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Aspects of carotid structure and function in health and different stages of chronic kidney disease

Journal article
Authors A. M. Asp
C. Wallquist
A. Rickenlund
B. Hylander
S. H. Jacobson
Kenneth Caidahl
M. J. Eriksson
Published in Clinical Physiology and Functional Imaging
Volume 38
Issue 3
Pages 402-408
ISSN 1475-0961
Publication year 2018
Published at
Pages 402-408
Language en
Links https://doi.org/10.1111/cpf.12429
Keywords arterial remodelling, arteriosclerosis, atherosclerosis, cardiovascular disease, carotid stiffness, carotid ultrasound, intima-media thickness, renal function
Subject categories Clinical Laboratory Medicine, Cardiovascular medicine

Abstract

INTRODUCTION: Arterial remodelling and stiffening have been demonstrated in end-stage renal disease (ESRD). The presence of vascular alterations in earlier-stage chronic kidney disease (CKD) is less studied. We evaluated vascular structure and function in mild-to-moderate CKD (stages 2-3) compared with healthy subjects and advanced CKD (stages 4-5). METHODS: Carotid ultrasound was performed in 103 non-dialysis CKD patients and 54 healthy controls. Carotid intima-media thickness (CIMT) and common carotid artery (CCA) diameter were measured. Strain, stiffness and the pressure-strain elastic modulus (Ep ) of the right CCA were calculated. RESULTS: There was no significant difference in CCA diameter between CKD 2-3 and controls. The CCA diameter was larger in CKD 4-5 compared with CKD 2-3 and controls (CKD 4-5, 6.50 +/- 0.79 mm versus CKD 2-3, 6.08 +/- 0.56 mm, P = 0.003; and versus controls 5.97 +/- 0.53 mm, P<0.001). However, after adjustments, the difference in CCA diameter was valid only for older ages and also dependent on systolic blood pressure (SBP). There were no significant differences in CIMT, strain or stiffness between the groups, but Ep was higher in CKD 4-5 compared with controls (P = 0.006). CONCLUSION: In mild-to-moderate CKD, there were no significant differences in carotid artery structure or function compared with healthy subjects. Only patients with advanced CKD and older ages showed signs of arterial remodelling. Our study indicates that vascular alterations occur in advanced CKD, with SBP and age as important contributing factors.

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