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Quality of life after percutaneous closure of patent foramen ovale in patients after cryptogenic stroke compared to a normative sample

Journal article
Authors Naqibullah Mirzada
Per Ladenvall
Per-Olof Hansson
Peter J Eriksson
Charles Taft
Mikael Dellborg
Published in International Journal of Cardiology
Volume 257
Pages 46-49
ISSN 0167-5273
Publication year 2018
Published at Institute of Health and Care Sciences
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 46-49
Language en
Keywords Quality of life, Patent foramen ovale (PFO), Cryptogenic stroke, PFO closure, sf-36 health survey, medical therapy, paradoxical embolism, recurrent, stroke, pfo, metaanalysis, prevalence, validity, events, Cardiovascular System & Cardiology
Subject categories Cardiac and Cardiovascular Systems


Aims: Despite the widespread use of percutaneous closure of patent foramen ovale (PFO) in patients after a cryptogenic stroke, little is known about its impact on health-related quality of life (HRQoL). The aim of this study was to assess HRQoL in these patients compared to PFO patients not considered candidates for percutaneous closure, and to a normal population. Methods and results: A total of 402 patients with cryptogenic stroke or transient ischaemic attack (TIA) who had been referred to our center for PFO closure were invited to a long-term clinical follow-up (mean follow-up 5.5 years; range 3-13 years). HRQoL was assessed using the SF-36 Health Survey and data were compared with an age-and gender-matched reference group from the Swedish SF-36 normative database. Fifteen patients had died and 43 did not answer the SF-36. Of the remaining 344 patients, 208 had undergone PFO closure, and 136 had not. The closure group and reference group reported similar HRQoL levels. However, the non-closure group showed significantly lower HRQoL in role limitation -physical, vitality, general health, mental health (p < 0.05) and social functioning (p = 0.05) than the reference group and also had significantly lower scores than the closure group, correcting for age differences, on physical functioning, role limitation - physical, vitality and general health (p < 0.05). Conclusions: Non-closure patients had lower HRQoL than their counterparts in the normal population and the closure group. Percutaneous PFO closure is associated with a favorable quality of life.

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