To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Altered peripheral amino … - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Altered peripheral amino acid profile indicate a systemic impact of active celiac disease and a possible role of amino acids in disease pathogenesis

Journal article
Authors Åsa Torinsson Naluai
Ladan Saadat Vafa
Audur Gudjonsdottir
H. Arnell
L. Browaldh
Staffan Nilsson
D. Agardh
Published in Plos One
Volume 13
Issue 3
ISSN 1932-6203
Publication year 2018
Published at Department of Mathematical Sciences
Institute of Biomedicine, Department of Microbiology and Immunology
Institute of Clinical Sciences
Language en
Keywords alanine, amino acid, glutamic acid, methionine, ornithine, proline, taurine, tryptophan, adolescent, amino acid analysis, amino acid blood level, Article, blood sampling, celiac disease, child, comparative study, controlled study, diet restriction, disease association, disease control, female, human, liquid chromatography-mass spectrometry, major clinical study, male, pathogenesis, tandem mass spectrometry
Subject categories Immunology in the medical area


Background: We have previously performed a Genome Wide Association and linkage study that indicated a new disease triggering mechanism involving amino acid metabolism and nutrient sensing signaling pathways. Objective: The aim of this study was to investigate if plasma amino acid levels differed among children with celiac disease compared with disease controls. Materials and methods: Fasting plasma samples from 141 children with celiac disease and 129 non-celiac disease controls, were analyzed for amino acid levels by liquid chromatography-tandem mass spectrometry (LC/MS). A general linear model using age and experimental effects as covariates was used to compare amino acid levels between children with a diagnosis of celiac disease and controls. Results: Seven out of twenty-three analyzed amino acids were elevated in children with celiac disease compared with controls (tryptophan, taurine, glutamic acid, proline, ornithine, alanine and methionine). The significance of the individual amino acids do not survive multiple correction, however, multivariate analyses of the amino acid profile showed significantly altered amino acid levels in children with celiac disease overall and after correction for age, sex and experimental effects (p = 8.4 × 10-8). Conclusion: These findings support the idea that amino acids could influence systemic inflammation and play a possible role in disease pathogenesis. © 2018 Torinsson Naluai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?