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Mitochondrial dynamics, mitophagy and biogenesis in neonatal hypoxic-ischaemic brain injury

Review article
Authors Claire Thornton
Adam Jones
Syam Nair
Afra Aabdien
Carina Mallard
Henrik Hagberg
Published in FEBS Letters
Volume 592
Issue 5
Pages 812-830
ISSN 0014-5793
Publication year 2018
Published at Institute of Neuroscience and Physiology, Department of Physiology
Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Pages 812-830
Language en
Links doi.org/10.1002/1873-3468.12943
Subject categories Neurosciences

Abstract

Hypoxic-ischaemic encephalopathy, resulting from asphyxia during birth, affects 2-3 in every 1000 term infants and depending on severity, brings about life-changing neurological consequences or death. This hypoxic-ischaemia (HI) results in a delayed neural energy failure during which the majority of brain injury occurs. Currently, there are limited treatment options and additional therapies are urgently required. Mitochondrial dysfunction acts as a focal point in injury development in the immature brain. Not only do mitochondria become permeabilised, but recent findings implicate perturbations in mitochondrial dynamics (fission, fusion), mitophagy and biogenesis. Mitoprotective therapies may therefore offer a new avenue of intervention for babies who suffer lifelong disabilities due to birth asphyxia.

Page Manager: Webmaster|Last update: 9/11/2012
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