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GISCOME – Genetics of Ischaemic Stroke Functional Outcome network: A protocol for an international multicentre genetic association study

Journal article
Authors Jane M Maguire
Steve Bevan
Tara M Stanne
Erik Lorenzen
Israel Fernandez-Cadenas
Graeme J Hankey
Jordi Jimenez-Conde
Katarina Jood
Jin-Moo Lee
Robin Lemmens
Christopher Levi
Bo Norrving
Kristiina Rannikmae
Natalia Rost
Jonathan Rosand
Peter M Rothwell
Rodney Scott
Daniel Strbian
Jonathan Sturm
Cathie Sudlow
Matthew Traylor
Vincent Thijs
Turgut Tatlisumak
Tadeusz Wieloch
Daniel Woo
Bradford B Worrall
Christina Jern
Arne Lindgren
Published in European Stroke Journal
Volume 2
Issue 3
Pages 229–237
Publication year 2017
Published at Institute of Neuroscience and Physiology
Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
Pages 229–237
Language en
Links https://doi.org/10.1177/23969873177...
Keywords Genetic association studies, stroke, functional outcome
Subject categories Neurology

Abstract

Introduction: Genome-wide association studies have identified several novel genetic loci associated with stroke risk, but how genetic factors influence stroke outcome is less studied. The Genetics of Ischaemic Stroke Functional outcome network aims at performing genetic studies of stroke outcome. We here describe the study protocol and methods basis of Genetics of Ischaemic Stroke Functional outcome. Methods: The Genetics of Ischaemic Stroke Functional outcome network has assembled patients from 12 ischaemic stroke projects with genome-wide genotypic and outcome data from the International Stroke Genetics Consortium and the National Institute of Neurological Diseases Stroke Genetics Network initiatives. We have assessed the availability of baseline variables, outcome metrics and time-points for collection of outcome data. Results: We have collected 8831 ischaemic stroke cases with genotypic and outcome data. Modified Rankin score was the outcome metric most readily available. We detected heterogeneity between cohorts for age and initial stroke severity (according to the NIH Stroke Scale), and will take this into account in analyses. We intend to conduct a first phase genome-wide association outcome study on ischaemic stroke cases with data on initial stroke severity and modified Rankin score within 60–190 days. To date, we have assembled 5762 such cases and are currently seeking additional cases meeting these criteria for second phase analyses. Conclusion: Genetics of Ischaemic Stroke Functional outcome is a unique collection of ischaemic stroke cases with detailed genetic and outcome data providing an opportunity for discovery of genetic loci influencing functional outcome. Genetics of Ischaemic Stroke Functional outcome will serve as an exploratory study where the results as well as the methodological observations will provide a basis for future studies on functional outcome. Genetics of Ischaemic Stroke Functional outcome can also be used for candidate gene replication or assessing stroke outcome non-genetic association hypotheses.

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