To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Cerebral microvascular ab… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Cerebral microvascular abnormalities in patients with idiopathic intracranial hypertension

Journal article
Authors V. A. Eidsvaag
Hans-Arne Hansson
K. Heuser
E. A. Nagelhus
P. K. Eide
Published in Brain Research
Volume 1686
Pages 72-82
ISSN 0006-8993
Publication year 2018
Published at Institute of Biomedicine
Pages 72-82
Language en
Keywords Benign intracranial hypertension, Brain capillary basement membrane, Pathology, Pericyte coverage, Pseudotumor cerebri, Pulsatile intracranial pressure
Subject categories Pathology


Aim: Idiopathic intracranial hypertension (IIH) is characterized by symptoms indicative of increased intracranial pressure (ICP), such as headache and visual impairment. We have previously reported that brain biopsies from IIH patients show patchy astrogliosis and increased expression of the water channel aquaporin-4 (AQP4) at perivascular astrocytic endfeet. Methods: The present study was undertaken to investigate for ultrastructural changes of the cerebral capillaries in individuals with IIH. We examined by electron microscopy (EM) biopsies from the cortical parenchyma of 10 IIH patients and 8 reference subjects (patients, not healthy individuals), in whom tissue was retrieved from other elective and necessary brain surgeries (epilepsy, tumors or vascular diseases). IIH patients were diagnosed on the basis of typical clinical symptoms and abnormal intracranial pressure wave amplitudes during overnight ICP monitoring. Results: All 10 IIH patients underwent shunt surgery followed by favorable clinical outcome. EM revealed abnormal pericyte processes in IIH. The basement membrane (BM) showed more frequently evidence of degeneration in IIH, but neither the BM dimensions nor the pericyte coverage differed between IIH and reference tissue. The BM thickness increased significantly with increasing age. Reference individuals were older than IIH cases; observations may to some extent be age-related. Conclusion: The present study disclosed marked changes of the cerebral cortical capillaries in IIH patients, suggesting that microvascular alterations are involved in the evolvement of IIH. © 2018 Elsevier B.V.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?