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Evolution of cerebrospinal fluid total α-synuclein in Parkinson's disease.

Journal article
Authors Marthe Gurine Førland
Annika Öhrfelt
Ole-Bjørn Tysnes
Kaj Blennow
Henrik Zetterberg
Kenn Freddy Pedersen
Guido Alves
Johannes Lange
Published in Parkinsonism & related disorders
Volume 49
Pages 4-8
ISSN 1873-5126
Publication year 2018
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 4-8
Language en
Links dx.doi.org/10.1016/j.parkreldis.201...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Neurochemistry

Abstract

Cerebrospinal fluid (CSF) total α-synuclein is considered a potential biomarker for Parkinson's disease (PD), but little is known about the evolution of this marker during the course of the disease. Our objective was to investigate whether CSF total α-synuclein concentrations change over time and are associated with motor and cognitive function in PD.CSF total α-synuclein concentrations were quantified in 56 longitudinally followed PD patients, 27 of whom provided CSF repeatedly 2 and/or 4 years later. Another 18 subjects were included as controls. The samples were analyzed using two independent, validated ELISA methods: our recently developed and validated in-house ELISA and a commercial kit from BioLegend.CSF total α-synuclein levels did not distinguish PD patients from controls, displayed no substantial changes during a period of up to 4 years, and did not predict subsequent motor or cognitive decline. These findings were consistent for both analytical methods.Our findings do not support the clinical utility of total α-synuclein as a single diagnostic or prognostic biomarker in PD.

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