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TAQ1A1 Allele of the DRD2 Gene Region Contribute to Shorter Survival Time in Alcohol Dependent Individuals When Controlling for the Influence of Age and Gender. A Follow-up Study of 18 Years.

Journal article
Authors Jan Balldin
Kristina Berglund
Ulf Berggren
Peter Wennberg
Claudia Fahlke
Published in Alcohol and Alcoholism
Volume 53
Issue 3
Pages 216–220
ISSN 1464-3502
Publication year 2018
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Department of Psychology
Pages 216–220
Language en
Links dx.doi.org/10.1093/alcalc/agx089
www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords alcohol withdrawal syndrome, alcohol dependence, alleles, ethanol, polymorphism, follow-up, genes, genotype, male, dopamine d2 receptor, mortality, gender, death, premature, drd2 gene, follow-up studies
Subject categories Psychology

Abstract

To investigate the influence of the A1 allele of the TAQ1A polymorphism in the dopamine D2 receptor (DRD2) gene region on mortality in adult individuals with alcohol dependence.The study sample consisted of 359 alcohol-dependent individuals treated for severe alcohol withdrawal symptoms in 1997. Years of survival was studied in an 18-year follow-up. In the analyses, gender and age were controlled for.At the 18-year follow-up, 53% individuals had deceased. The analyses showed that older age (P < 0.001), male gender (P < 0.05) and carrying the A1 allele (P < 0.01) all significantly and independently contributed to shorten years of survival. Among the deceased individuals, the genotype A1+ was the only significant contributor to shorten years of survival.An important contribution of the present study is that in alcohol dependence the Taq1A1 allele of the DRD2 gene region is a risk factor for premature death of similar importance as the well-known risk factors of age and gender.We investigated the influence of A1 allele of the TAQ1A polymorphism in DRD2 receptor gene region on mortality in alcohol-dependent individuals in an 18-year follow-up. Age, gender and the A1 allele contributed to shorten years of survival. Among the deceased, the A1+ was the only contributor to shorten years of survival.

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