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Vesicle impact electrochemical cytometry compared to amperometric exocytosis measurements

Journal article
Authors J. Dunevall
Soodabeh Majdi
Anna Larsson
Andrew G Ewing
Published in Current Opinion in Electrochemistry
Volume 5
Issue 1
Pages 85-91
ISSN 2451-9103
Publication year 2017
Published at Department of Chemistry and Molecular Biology
Pages 85-91
Language en
Links dx.doi.org/10.1016/j.coelec.2017.07...
Keywords fluorescent false neurotransmitters, vesicular volume, chromaffin cells, pc12 cells, release, transmitters, microscopy, events, fusion, size, Electrochemistry, ates of america, v88, p10754, en tk, 1994, analytical chemistry, v66, p3031, toledo ga, 1993, nature, v363, p554
Subject categories Biochemistry and Molecular Biology, Chemical Sciences

Abstract

Three new tools are discussed for understanding chemical communication between cells and primarily to delve into the content and structure of nanometer transmitter vesicles. These are amperometric measurements of exocytosis, vesicle impact electrochemical cytometry, and intracellular vesicle impact electrochemical cytometry. These are combining in the end nanoscale mass spectrometry imaging to begin determination of vesicle structure. These methods have provided solid evidence for the concept of open and closed exocytosis leading to partial release of the vesicle content during normal exocytosis. They have also been used to discover cases where the fraction of transmitter released is not changed, and other cases where the vesicle transmitter fraction released is altered, as with zinc, thought to alter cognition. Overall, the combination of these methods is showing us details of vesicular processes that would not be measureable without these micro and nano electrochemical methods.

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