To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Effects of androgens on t… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Effects of androgens on the leptin system in immature male Atlantic salmon parr

Journal article
Authors S. Trombley
A. Rocha
Björn Thrandur Björnsson
B. Borg
M. Schmitz
Published in General and Comparative Endocrinology
Volume 257
Pages 122-129
ISSN 0016-6480
Publication year 2018
Published at Department of Biological and Environmental Sciences
Pages 122-129
Language en
Links dx.doi.org/10.1016/j.ygcen.2017.08....
Keywords Leptin, Leptin receptor, Testosterone, 11-ketotestosterone, Reproduction, Brain-pituitary-gonad axis, trout oncorhynchus-mykiss, early sexual-maturation, beta-subunit gene, adult-rat testis, rainbow-trout, in-vitro, receptor expression, genomic, characterization, tissue distribution, feedback-control, Endocrinology & Metabolism
Subject categories Endocrinology and Diabetes

Abstract

Leptin modulates all levels of the reproductive endocrine axis in mammals, and in turn, both leptin and the leptin receptor are regulated by sex steroids. The aim of this study was to investigate if sex steroids regulate the leptin system also in fish. Immature one-year old male Atlantic salmon parr were implanted with Silclear capsules that were either empty or filled with 11-ketoandrostenedione (11 KA) or testosterone (T) and the effects of 35-days treatment were investigated on measures of maturation, gene expression of leptin (lepa1, lepa2), leptin receptor (lepra1) and circulating plasma leptin. Both 11-KA and T stimulated the reproductive axis by increasing testes weight and up-regulated pituitary lh-beta mRNA levels and for T also fsh-beta. T up-regulated transcription levels of lepa1 and lepra1 in the pituitary, while 11-KA had no effect. Leptin receptor expression in the testis was unaltered by either androgen. T up-regulated lepa1 mRNA levels significantly also in the liver, but had no effect on lepa2, and 11 KA did not affect hepatic gene expression of either lepa1 or lepa2. Plasma leptin levels did not differ significantly between treatments. The results indicate that androgens regulate gene expression of leptin and the leptin receptor in different tissues in fish and that the effects of leptin might be tissue specific considering plasma levels remained unaltered. Overall, the results suggest a role for leptin in fish reproduction, where sex steroids are able to regulate components of the leptin system differentially in liver and important tissues of the reproductive axis. (C) 2017 Elsevier Inc. All rights reserved.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?