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Histomorphometric analyses of area fraction of different ratios of Bio-Oss((R)) and bone prior to grafting procedures - An in vitro study to demonstrate a baseline

Journal article
Authors H. Aludden
Anna Dahlin
T. Starch-Jensen
Christer Dahlin
A. Mordenfeld
Published in Clinical Oral Implants Research
Volume 29
Issue 2
Pages 185-191
ISSN 0905-7161
Publication year 2018
Published at Institute of Clinical Sciences, Department of Biomaterials
Pages 185-191
Language en
Keywords alveolar ridge augmentation, bone substitute, dental implants, histology, sinus floor augmentation, anorganic bovine bone, sinus floor augmentation, horizontal ridge, augmentation, particulated autogenous bone, prospective case series, mineral bio-oss, implant placement, deproteinized bovine, clinical-trial, histologic evaluation, Dentistry, Oral Surgery & Medicine, Engineering
Subject categories Biomaterials


ObjectiveThe objective of this study was to estimate the area fraction of different ratios of Bio-Oss((R)) and bone, prior to grafting in an in vitro model to demonstrate a histomorphometric baseline. MethodsBio-Oss((R)) particles were mixed with autogenous bone from pig jaw in three different ratios (50:50, 80:20 and 100:0) and packed in rice paper in a standardized procedure. Histomorphometric analyses were performed in 25 specimens and 74 regions of interest. The area percentage of Bio-Oss((R)), bone, and non-mineralized tissue (NMT) were calculated. Results were reported as mean values and 95% confidence interval (CI). ResultsThe mean area fraction of Bio-Oss((R)) was 20.6% (CI: 18.2-23) in the 50:50 mixture, 33.6% (CI: 29.7-37.6) in the 80:20 mixture, and 43.4% (CI: 40.5-46.3) in the 100:0 mixture. The mean area fraction of NMT was 60.5% (CI: 57.9-63.1) in the 50:50 mixture, 59.6% (CI: 56.4-62.7) in the 80:20 mixture, and 56.6% (CI: 53.7-59.5) in the 100:0 mixture. The mean area fraction of bone was 18.9% (CI: 16.9-20.9) in the 50:50 mixture and 6.8% (CI: 5-8.6) in the 80:20 mixture. ConclusionThere is a great difference in the clinically estimated percentage and the histomorphometrically evaluated percentage of Bio-Oss((R)) at baseline, prior to grafting. The area fraction of different tissues presented in this study may be beneficial as guidance for histomorphometrical baseline calculations when different mixtures of Bio-Oss((R)) and autogenous bone are used as grafting materials.

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